Influence of herbal extracts in physicochemical properties and stability of antibacterial gels

ZAMORA, CRISTINA MARISEL PÉREZ; MICHALUK, ARIEL GERMÁN; TORRES, CAROLA ANALÍA; MOURIÑO, VIVIANA; CHIAPPETTA, DIEGO ANDRÉS; NUÑEZ, MARÍA BEATRIZ

Journal of Advanced Pharmacy Education and Research

SPER

Lugar: Estambul; Año: 2023 vol. 13 p. 16 - 24

The use of plants to treat diseases and heal wounds is a custom that dates back thousands of years and is a legacy of ancient civilizations. Although a significant proportion of the planet´s plant biodiversity is found on the American continent, there are very few pharmaceutical products developed from it. This work aimed to develop and characterize topical formulations (gels and emulgels), including a combination of plant extracts with recognized antibacterial activity. Hydroalcoholic extracts of Lippia turbinata Griseb. and Lippia alba (Mill.) N. E. Brown were obtained by leaching. The excipients used were Carbopol® 934 and 940, Sepigel® 305, sodium carboxymethylcellulose, methylcellulose, propylene glycol, and ethanol. The finished product was characterized by properties: organoleptic characteristics, extensibility, pH, texture profile, permeation performance, and microbiological quality. Then, they were subjected to stability studies in different conditions of temperature and humidity. They had a characteristic smell of plant species, color brown, without the presence of lumps, and with good extensibility. The gels had an in vitro permeation of porcine skin of up to 30% and low retention in the epithelium (