Transition metal complexes with 6 methoxyquinolin as antitumor agents. Biological studies on two and three-dimensional cell cultured models. .

CADAVID-VARGAS J.F; VILLAPEREZ C ; RUIZ M.C; LEON I.E; VALENCIA G.C; SORIA B; DI VIRGILIO A.L; ETCHEVERRY S.B

Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica, Reunión Anual de la Sociedad Argentina de Fisiología (SAIC-SAFIS); 2016

Coordination complexes have been extensively studied as antiproliferative agents , offering a potential alternative for cancer treatment. Both, the ligand and the metal play an important role in the pharmacological properties of the complex.This study evaluates the effect of 6-methoxyquinoline complexes with copper, zinc and silver as antitumoral agents in 2D (monolayer) and a 3D (multicellular spheroids) models derived from A549 and MG-63 cell lines. Ag, Cu and Zn complexes significantly reduced the cell viability (P