Oxidovanadium(IV) Complexes with Flavonoids: activation of nfkb and apoptosis in HT-29 cell line

LEON I.E ; PORRO V; TISCORNIA I; DI VIRGLIO AL; BOLLATI-FOGOLIN M.; ETCHVERRY SB

Congreso; XLVIV Reunión Anual de la Sociedad de Bioquímica y Biología Molecular (Molecular mechanisms in cell signaling and gene expresión, SAIB 2013); 2013

Polyphenolic flavonoids present anti-inflammatory and anti-tumor effects. In particular, Chrysin and Silibinin exhibit anti-proliferative and anti-metastatic effects against various malignant cell lines. In this work we report the biological effects of two complexes of vanadyl(IV) with Chrysin and Silibinin on a human colon adenocarcinoma cell line (HT-29 ATCC HTB 38). VOsil caused an inhibitory effect on cell viability in the range of 75-100 µM while VOchrys only provoked this effect at 100 µM (p