In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells

BALSA, LUCIA M.; QUISPE, PATRICIA; BARAN, ENRIQUE J.; LAVECCHIA, MARTIN J.; LEÓN, IGNACIO E.

METALLOMICS

ROYAL SOC CHEMISTRY

Año: 2020 vol. 12 p. 1931 - 1940

1756-5901

The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(iv) complex [VO(clioquinol)2], VO(CQ)2, and its regulation of FAK. In particular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells.