Mononuclear Pd( ii ) and Pt( ii ) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

MATESANZ, ANA I.; JIMENEZ-FARACO, EVA; RUIZ, MARÍA C.; BALSA, LUCIA M.; NAVARRO-RANNINGER, CARMEN; LEÓN, IGNACIO E.; QUIROGA, ADORACION G.

Inorganic Chemistry Frontiers

Royal Society Chemistry

Año: 2017

Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designedand characterized showing mononuclear structures. An important pharmacological property for both compounds is thehigh selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows higher antitumor activityand selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models(pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show thatthe Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and weprovide new insight into the design and synthesis of palladium compounds as potential antitumor agents.