Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line

LEON I.E; ETCHEVERRY S.B; BARAN E.J

Biotechnology, An Indian Journal

Trade Science Inc

Año: 2015

The cytotoxicity activity of the recently reported[VO(H2O)2(SO4)dppz]2H2O complex (dppz = dipyrido[3,2-a:2’,3’-c]phenazine) on MG-63 human osteosarcoma cell line was investigated.It was found that it caused a concentration related inhibitory effect in theconcentration range between 5 and 25 Mand diminished the cell viabilityca. 40% in the range from 25 to 100 ìM, without dose/response effectsin this range. These biological effects are, in general, similar to thosepreviously reported for the related [VO(ODA)dppz]3H2O (ODA= dianionof oxodiacetic acid) and [VO(ODA)(phen)]1.5H2O (phen = ophenanthroline)complexes. The importance of the presence of DNAintercalatingligands in these complexes is emphasized.