A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz: Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line.

LEON IE; PARAJON- COSTA B.; FRANCA C; ETCHEVERRY S.B; BARAN E.J

BIOLOGICAL TRACE ELEMENT RESEARCH

HUMANA PRESS INC

Lugar: Oregon; Año: 2015

0163-4984

The oxidovanadium(IV) complex of oxodiacetic acid (H2ODA) and dppz (dipyrido [3,2-a:2?,3?-c] phenazine) of stoichiometry [VO(ODA)(dppz)]3H2O could be synthesized for the first time by reaction between [VO(ODA)(H2O)2] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 M and diminished the cell viability ca. 45% in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]1.5H2O complex.