Spectroscopic Characterization of an Oxovanadium(IV) Complex of Oxodiacetic Acid and 2,2?-Bipyridine. Bioactivity on Osteoblast-Like Cells in Culture _________________________________________________

LEÓN IE, ; ETCHEVERRY S.B; PARAJON- COSTA B.; BARAN E.J

JOURNAL OF THE MEXICAN CHEMICAL SOCIETY

SOC QUIMICA MEXICO

Año: 2013 vol. 57 p. 189 - 193

1870-249X

The oxovanadium(IV) complex of oxodiacetic acid (H2ODA) and 2,2?-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]H2O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)]H2O can be considered as a good candidate to be further investigated in relation to cancer treatment.