Antitumor properties of a vanadyl(IV) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: role of the oxidative stress and apoptosis

LEON I.E, ; DI VIRGILIO A.L; PORRO V.; MUGLIA C; NASO L.G; WILLIAMS PAM; BOLLATI-FOGOLIN M.; ETCHEVERRY SB

DALTON TRANSACTIONS

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2013 vol. 42 p. 11868 - 11880

1477-9226

Flavonoids, a polyphenolic compound family and the vanadium compounds have interesting biological, pharmacological, and medicinal properties. We report herein the antitumor actions of the complex [VO(chrysin)2EtOH]2 (VOchrys) on MG-63 human osteosarcoma cell line. Oxovanadium(IV), Chrysin and VOchrys caused a concentration-dependent inhibition of cell viability The complex was the most strong antiproliferative agent (p