Integrated assessment of ivermectin kinetics, metabolism and tissue residues in laying hens

MORENO L, DOMINGUEZ P, FARÍAS C, CANTÓN L, VIRKEL G, MATÉ L, CEBALLOS L, LANUSSE C, ALVAREZ L.

Nantes

Congreso; 13º International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPPT); 2015

Asociación Europea para Farmacología y Toxicología Veterinaria

IVM pharmacokinetic behaviour in laying hens is characterized by larger apparent volume of distribution and higher plasma clearance compared to mammalian species. IVM half-life was shorter and plasma exposure lower than in other species, probably associated to a higher excretion/metabolism. IVM tissue residues were below the MRLs established for mammalian species. Residues quantified in eggs were greater than some MRLs values, suggesting that a withdrawal period would be necessary for eggs after IVM oral administration in laying hens.