INVESTIGADORES
GARELLI Andres
artículos
Título:
Relationship Between a7 nAChR and Apoptosis in Human Lymphocytes
Autor/es:
DE ROSA, MARIA JOSE; ESANDI, MC; GARELLI, ANDRES; RAYES, DIEGO; BOUZAT, CECILIA
Revista:
JOURNAL OF NEUROIMMUNOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2005 vol. 160 p. 154 - 161
ISSN:
0165-5728
Resumen:
The presence of nicotinic receptors (nAChRs) in blood cells has been
demonstrated. However, little is known about their functional roles. We
have detected mRNA of alpha7 nAChR in peripheral human lymphocytes and
determined that its expression is highly variable among individuals and
within the same individual at different times. Upregulation of alpha7 is
systematically observed after incubation of lymphocytes with nicotine
or alpha-bungarotoxin. In addition, the incubation with these drugs
decreases the percentage of apoptotic cells induced by the exposure to
cortisol. Our results suggest that alpha7 nAChRs are involved in the
modulation of cortisol-induced apoptosis.
