Oxidative processes of brain damage induced by Copper and Iron

MUSACCO SEBIO, R; SAPORITO, C.; FERRAROTTI, N.; REPETTO, M

Sao Pedro

Congreso; VII Meeting of the South American Group of the Society for Free Radical Biology and Medicine; 2011

Society for free radical biology and medicine. South American Group

Copper (Cu) and iron (Fe) toxicities are associated to the etiology of neurodegenerative diseases. The mechanisms currently considered are a Haber-Weiss reaction and a depletion of reduced glutathione (GSH) and protein SH groups. Objective: to compare oxidative damage (OD) and time course of OD induced by Cu and Fe in rat brain; to correlate OD with redox status (Pearson´s factor, r, p