Effect of dietary supplementation with resveratrol, alpha-tocopherol and piperine on oxidative stress and inflammation in older adults with risk factors for metabolic syndrome

FABIANA LAIRION; RAUL PASTOR; ZULMA MANFREDI; CHRISTIAN SAPORITO; ALEJANDRA CIMATO; ISABEL PASTOR; MATÍAS LASSO; ALDANA RODRIGUEZ; MANUELA SORENSEN; LILA LOPEZ MONTAÑANA; MARGARITA MARTINEZ SARRASAGUE; ROBERTO LEMOLI; MARISA GABRIELA REPETTO

CIUDAD AUTONOMA BUENOS AIRES

Congreso; 66º Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2021

Sociedad Argentina de Investigación Clínica

EFFECT OF DIETARY SUPPLEMENTATION WITH RESVERATROL, ALPHA-TOCOPHEROL AND PIPERINE ON OXIDATIVE STRESS AND INFLAMMATION IN OLDER ADULTS WITH RISK FACTORS FOR METABOLIC SYNDROMEFabiana Lairion1,2, Raúl Pastor1, Zulma Manfredi1, Christian Saporito Magriñá1,2, Alejandra Cimato1,2, Isabel Pastor1, Matías Lasso1, Aldana Rodriguez1, Manuela Sorensen1, Lila López Montañana1, Margarita Martinez Sarrasague1,2, Roberto Iermoli1, Marisa Gabriela Repetto1,2 1University of Buenos Aires, Buenos Aires, Argentina, 2IBIMOL, UBA-CONICET, Buenos Aires, Argentina, Oxidative stress, hypertension, blood glucose level and lipid profile are risk factors for metabolic syndrome (MS) and cardiac disease in older adults. The aim of this study is evaluate the protective role of resveratrol supplementation on chronic inflammation and oxidative stress associated to MS. Voluntary patients with a diagnosis of MS (n=92) based on the diagnostic criteria of the National Cholesterol Education Program, Adult treatment Panel III, 2002 received a dietary supplement (RTP: 50 mg resveratrol, 25 mg alpha-tocopherol and 5 mg piperine) along with their usual treatment for a period of 3 months. Piperine increases resveratrol and alpha-tocopherol absorption. Control was the patient himself in baseline conditions, avoiding interindividual variables and bioavailability of active principles. Venous blood was collected from 23 patients (68 ± 5 years), and biochemical markers were assessed in plasma: protein oxidation (measured as carbonyl protein, CO), and interleukin 6 (IL-6); and in red blood cells (RBC): catalase activity. Patients were classified into 3 groups according to the amount of risk factors (blood glucose, HDL cholesterol, triglycerides, waist circumference and blood pressure) for MS: 3/5 (n=7), 4/5 (n=5) and 5/5 (n=11) risk factors. Preliminary results showed increase in catalase activity (22-32%, p