Immunoglobulin M nephropathy: Histopathological and clinical characteristics. Case series Nefropatía por inmunoglobulina M: Características histopatológicas y clínicas. Serie de casos

BATTAGLIA, LUCIANA MENI; BALESTRACCI, ALEJANDRO; TOLEDO, ISMAEL; MARTIN, SANDRA M.; CAREAGA, CLAUDIA M.; GOGORZA, MARÍA C.; CAUPOLICAN, ALVARADO; CAO, GABRIEL

ARCHIVOS ARGENTINOS DE PEDIATRIA

SOC ARGENTINA PEDIATRIA

Año: 2021 vol. 119 p. 335 - 339

0325-0075

Immunoglobulin M nephropathy (IgMN) is an idiopathic glomerulopathy characterized by diffuse global mesangial deposits of IgM. We retrospectively studied the clinical and histopathological characteristics of the patients with IgMN seen in our service. Of 241 renal biopsies, 21 corresponded to IgMN (8.7 %). One patient was excluded due to associated systemic disease and 2 due to follow-up less than 1 year, 18 were included (14 girls, median age 3.08 years). Fourteen manifested with nephrotic syndrome (NS) and the remaining with proteinuria (isolated or associated with hematuria). On light microscopy, 13 had hyperplasia with mesangial expansion and 5 had focal and segmental sclerosis. Of the patients with NS, 7 were steroid-resistant, 4 steroid-dependent, and 3 frequent relapsers. All patients with NS and 1 with proteinuria-hematuria received immunosuppressants; the 18 patients also received antiproteinuric drugs. After 5.2 years (2-17.5) of follow-up, 6 patients developed chronic kidney disease.