"Sex Chromosome Complement involvement in the sexually dimorphic vasopressinergic system". Symposium 5: Sex differences in vasopressin signalling: a whole body perspective.

CAEIRO X

Mangaratiba

Simposio; 12th World Congress on Neurohypophysal Hormones; 2017

Sex Chromosome Complement involvement in the sexually dimorphic vasopressinergic systemXimena E. CaeiroInstituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET - Universidad Nacional de Córdoba, Cordoba, Argentina, Arginine vasopressin (AVP) is involved in the control of blood pressure and water balance. Basic and clinical data suggest there are sex differences in the expression and function of AVP that cannot be entirely explained solely as a result of gonadal steroid action. In order to evaluate whether sex chromosome complement (SCC) may differentially modulate well known sex differences in the vasopressinergic system we used the "four core genotype" mouse model. In these transgenic mice the effect of gonadal sex and SCC are dissociated, allowing comparisons of sexually dimorphic traits between XX and XY females as well as in XX and XY males. Comparing these genotypes, it is possible to segregate the role of a) SCC (comparing mice with the same gonadal type but different SCC: XX vs. XY) b) sex (females vs. male) and c) the interaction of SCC and sex. Our main results reveal a modulatory effect of sex chromosome complement on AVP gene expression under basal and water deprived conditions within the SON. In this symposium will also discuss our results regarding c-fos expression within the hypothalamic vasopressinergic nuclei after water deprivation.Understanding in more detail the sources of physiological differences between males and females may offer important insights into designing improved oriented sex-tailored therapeutic treatments in the future.Support or Funding InformationSupported by: ANPCyT, ISN, SECyT, MincytCba, CnPq, CONICET.