SEXUAL DIMORPHISM IN BLOOD PRESSURE REGULATION AND BODY FLUID HOMEOSTASIS. Simposio 3.“Enfermedades Silenciosas que afectan al ser humano”

DADAM, FLORENCIA; GONZALEZ, LIHUE; GODINO, ANDREA; VIVAS, LAURA; CAEIRO, XIMENA E

San Juan

Congreso; XLI CONGRESO SOCIEDAD DE BIOLOGIA DE CUYO; 2023

Sociedad de Biología de Cuyo

SEXUAL DIMORPHISM IN BLOOD PRESSURE REGULATION AND BODY FLUID HOMEOSTASISDadam, Florencia1; Gonzalez, Lihue; Godino, Andrea1; Vivas, Laura1; Caeiro, Ximena E.1 1Instituto de Investigación Médica M. y M. Ferreyra, INIMEC-CONICET, Universidad Nacional Córdoba, Córdoba, Argentina. xcaeiro@immf.uncor.eduClinical and experimental studies indicate that sex matters when it comes to blood pressure regulation, rates of cardiovascular disease, symptoms and risk factors. Although awareness of sex differences in cardiovascular disease is increasing, much of what we know about blood pressure regulation has been derived from studies in males. However, principles learned in male models do not necessarily apply to females, and this addresses the importance of studying in more detail the sources of physiological disparity between sexes.Angiotensin and vasopressin differentially modulate hydroelectrolyte and cardiovascular responses in male and female. But, are the hormonal factors the only to blame for such differences? Sex steroids can induce organizational (long-lasting or permanent) effect during critical periods of development but can also impart (temporary or reversible) activational effects. Furthermore, males and females differ not only in their sex (males are born with testes- and females with ovaries-hormonal factors) but also carry different sex chromosome complements (XY and XX respectively), and thus are influenced throughout life by different genomes.In this symposium, we will discuss our studies in which we have dissected the contribution of the sex chromosome complement factor, organizational and activational hormonal effects on sex-related differences in angiotensinergic and vasopressinergic involvement in blood pressure regulation and body fluid homeostasis.