Sex chromosome complement involvement in angiotensin receptor sexual dimorphism

DADAM FM; CISTERNAS CD; MACCHIONE AF; GODINO A; ANTUNES-RODRIGUES J,; CAMBIASSO MJ; VIVAS LM; CAEIRO XE

MOLECULAR AND CELLULAR ENDOCRINOLOGY.

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2017 vol. 15 p. 98 - 105

0303-7207

This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sexdifferences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrainnuclei and at medulla/cortical kidney.Samples were collected from gonadectomized male (XX and XY) and female (XX and XY) mice of the?four core genotypes? model. At brain level, a SCC effect at the area postrema was demonstrated. Anincrease in mRNA level of Agtr1a and Agtr1a/Agtr2 ratio in XY-SCC mice was associated with a decreasein Mas1 compared to XX-SCC mice. In the renal cortex, a SCC effect for Agtr2 and Mas1 was observed.Regardless of sex (male or female), XX-SCC mice expressed higher levels of mRNA Agtr2 and Mas1 thanXY-SCC mice {F(1,12) ¼ 6,126,p < 0.05; F(1,21) ¼ 5,143,p < 0.05}. Furthermore, XX-female mice showed asignificant increase in Mas1 expression compared to XY-female mice.These results reveal a SCC modulatory effect at central and kidney level on angiotensin receptorexpression, with an enhancement of the vasodilatory arm in XX-mice and an increase in the vasoconstrictionarm in XY-mice, which may underlie sex differences in the regulation of arterial pressure.© 2017 Elsevier B.V. All rights reserved.