M2 macrophages inhibit IFN- production of NK cells through TGF-B and NK cell-mediated cytotoxicity through cell-to-cell contact

NUÑEZ SY; ZIBLAT A; SECCHIARI F; TORRES NI; SIERRA JM; ARAYA RE; IRAOLAGOITIA XL; DOMAICA CI; FUERTES MB; ZWIRNER NW

Mar del Plata

Congreso; LXIV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA; 2016

SAI

Macrophages are highly plastic cells that can modify their functional response according to the surrounding microenvironment, becoming pro-inflammatory (M1) or anti-inflammatory (M2) macrophages. The outcome of the crosstalk between M1 and NK cells is well established playing a critical role in the protection against infections and tumor growth. However, the effect of M2 on NK cells is less clear. We previously demonstrated that M2 macrophages inhibit NK cell degranulation (n=8, p