NK cell-mediated recruitment of dendritic cells to the tumor negatively impacts on anti-tumor CD8 T-cell priming

IRAOLAGOITIA XL; SPALLANZANI RG; TORRES NI; DOMAICA CI; ZWIRNER NW; FUERTES MB

Congreso; LIX Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica y LXII Reunión Científica Anual de la Sociedad Argentina de Inmunología.; 2014

SAIC-SAI

Spontaneous T cell priming can occur in response to a growing tumor and the presence of activated CD8 T cells has positive prognostic value. However, the innate immune mechanisms that regulate the adaptive antitumor immune responses remain ill-defined. NK cells are the first line of defense against tumors and can secrete cytokines and chemokines. However, a role of NK cells in dendritic cell (DC) recruitment to tumor microenvironment has not been pursued. Thus, the aim of this work was to study the NK cell-mediated DC recruitment and its impact on CD8 T-cell priming during the anti-tumor response. We performed transwell cell migration assays and we found that supernatants from tumor-primed NK cell recruited immature DCs (p