INVESTIGADORES
QUIROGA Ariel Dario
artículos
Título:
Carboxylesterase1/Esterase-x regulates chylomicron production in mice
Autor/es:
QUIROGA, ARIEL DARIO; LIAN, JIHONG; LEHNER, RICHARD
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2012 p. 1 - 11
ISSN:
1932-6203
Resumen:
Abstract
Elevated postprandial plasma
triacylglycerol (TG) concentrations are commonly associated with obesity and
the risk of cardiovascular disease. Dietary fat contributes to this condition
through the production of chylomicrons. Carboxylesterases have been mainly
studied for their role in drug metabolism, but recently they have been shown to
participate in lipid metabolism; however, their role in intestinal lipid
metabolism is unknown. Carboxylesterase1/esterase-x (Ces1/Es-x) deficient mice
become obese, hyperlipidemic and develop hepatic steatosis even on standard
chow diet. Here, we aimed to explore the role of Ces1/Es-x in intestinal lipid
metabolism. Six-month old wild-type and Ces1/Es-x deficient mice were
maintained on chow diet and intestinal lipid metabolism and plasma chylomicron
clearance were analyzed. Along the intestine Ces1/Es-x protein is expressed only
in proximal jejunum. Ablation of Ces1/Es-x expression results in postprandial
hyperlipidemia due to increased secretion of chylomicrons. The secreted
chylomicrons have aberrant protein composition, which results in their reduced
clearance. In conclusion, Ces1/Es-x participates in the regulation of
chylomicron assembly and secretion. Ces1/Es-x might act as a lipid sensor in
enterocytes regulating chylomicron secretion rate. Ces1/Es-x might represent an
attractive pharmacological target for the treatment of lipid abnormalities
associated with obesity, insulin resistance and fatty liver disease