INVESTIGADORES
QUIROGA Ariel Dario
artículos
Título:
Attenuation of the Wnt/b-catenin/TCF pathway by in vivo interferon-a2b (IFN-a2b) treatment in preneoplastic rat livers
Autor/es:
PARODY, JUAN PABLO; ALVAREZ, MARIA DE LUJAN; QUIROGA, ARIEL DARIO; CEBALLOS, MARIA PAULA; FRANCES, DANIEL ELEAZAR ANTONIO; PISANI, GERARDO BRUNO; PELLEGRINO, JOSE MANUEL; CARNOVALE, CRISTINA ESTER; CARRILLO, MARÍA CRISTINA
Revista:
GROWTH FACTORS
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Año: 2010 p. 1 - 12
ISSN:
0897-7194
Resumen:
Wnt/b-catenin/T cell factor (TCF) pathway is activated in
several types of human cancers, promoting cell growth and proliferation.
Forkhead box containing protein class O (FOXO) transcription factors compete
with TCF for b-catenin binding, particularly under cellular oxidative stress
conditions. Contrary to b-catenin/TCF, b-catenin/FOXO promotes the transcription
of genes involved in cell cycle arrest and apoptosis.We have previously
demonstrated that in vivo interferon-a2b (IFN-a2b) administration induces
apoptosis in preneoplastic livers, a mechanism mediated by reactive oxygen
species (ROS) and transforming growth factor-b1 (TGF-b1). This study was aimed
to assess the status of the Wnt/b-catenin/TCF pathway in a very early stage of
rat hepatocarcinogenesis and to further evaluate the effects of in vivo IFN-a2b
treatment on it. We demonstrated that the Wnt/b-catenin/TCF pathway is
activated in preneoplastic rat livers. More important, in vivo IFN-a2b treatment
inhibits Wnt/b-catenin/TCF pathway and promotes programed cell death possibly
providing a link with FOXO pathway.