Technological delivery systems to improve biopharmaceutical properties?

GARNERO, C.; ZOPPI, A.; ALOISIO, C.; LONGHI, M.

Nanoscale fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology

El Sevier

Lugar: Amsterdam; Año: 2017; p. 253 - 299

A large number of drugs of therapeutic interest presents inappropriate physico-chemical properties (e.g. low dissolution rate, solubility, or permeability in biological fluids) that result in formulations with low bioavailability and large inter-subject variability, producing therapeutic problems related to therapeutic effectiveness. Thus, one of the greatest challenges for the pharmaceutical field today is the application of technological formulations as strategies to enhance their bioavailability. This chapter focuses on the design of systems with promising properties based on the intermolecular interactions of the components, considering the formulation and manufacturing techniques of the delivery systems, as well as the factors that may affect the drug and the pharmaceutical form. Specifically, we will describe the crucial role of the innovative systems, including binary and multicomponent complexes with cyclodextrins, microemulsions, solid self-microemulsifying drug delivery systems and solid lipid nanoparticles. We will highlight the feasibility of these to improve biopharmaceutical properties.