Korsmeyer-Peppas, Peppas-Sahlin, and Brazel-Peppas: Models of Drug Release

ALAN TALEVI; MARÍA ESPERANZA RUIZ

The ADME Encyclopedia. A Comprehensive Guide on Biopharmacy and Pharmacokinetics

Springer

Lugar: Basel; Año: 2021; p. 1 - 9

Peppas model of drug release (usually regarded as power law) describes drug release from polymeric drug delivery systems, establishing a simple exponential relationship (in contrast with cumbersome exact analysis) between fractional drug release and the release time. The exponent of release n (also called diffusional or transport exponent) provides information on the possible mechanism(s) of drug release at play.Although the power law was previously known in the context of solute desorption (it was already mentioned in 1956, in the first edition of Crank?s classic book, The Mathematics of Diffusion [1]), Korsmeyer and Peppas were possibly the first to report its applicability in the context of drug delivery, as part of Richard Korsmeyer?s MS thesis in 1981 [2, 3]. In this first report from Peppas groups, Eq. (1) was used to describe the drug release from planar hydrophilic, polymeric matrixes (hydrogels of poly(vinyl alcohol, PVA that carried theophylline as model drug) [2], but the applicability of the Korsmeyer-Peppas/Ritger-Peppas model was later verified for other systems and geometries and even successfully applied to describe the drug release from substantially different compositions, vehicles, and drug delivery systems (for instance, liposomes [4, 5]).