Baker-Lonsdale model of drug release

ALAN TALEVI; MARÍA ESPERANZA RUIZ

The ADME Encyclopedia. A Comprehensive Guide on Biopharmacy and Pharmacokinetics

Springer

Lugar: Basel; Año: 2021; p. 1 - 7

The Baker-Lonsdale model describes the drug release from spherical monolithic drug delivery devices, in which the active pharmaceutical ingredient is initially dispersed throughout an inert diffusion matrix. It was derived from prior work by Higuchi on finely dispersed drug particles in an ointment base (in fact, it has been referred by some authors as Higuchi, Baker, and Lonsdale model). Higuchi originally assumed a flat geometry (thin film, slab); however, he later adapted his model to spherical geometries, in a similar manner that Baker and Lonsdale did. In principle, the Baker-Lonsdale model is applied to homogeneous polymeric matrix systems (with no pores, fractures, or capillaries), through which transport occurs by dissolution of the permeating species in the polymer, and subsequent diffusion down a concentration gradient. In essence, the release kinetics are estimated by solving Fick?s laws with the appropriate boundary conditions.