Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats

RAGONE, M.I.; BAYLEY, M.; LAZARTE, M.L.; CLAVELLINO, L.; PRIETO, J.J.; RUIZ, M.E.; CAPONE, E.; CONSOLINI, A.

Pharmacology on line

SILAE - Società Italo-Latinoamericana di Etnomedicina

Lugar: Salerno; Año: 2019 vol. 3 p. 1 - 14

1827-8620

Drinking infusions of Melissa officinalis (Moff, ?lemon balm?) or Bahuinia forficata (Baf, ?cow´s hoof?) are clinically contraindicated in hypothyroidism (HypoT). However, it is not known whether they interfere in the cardiac response to coronary dysfunction. So, the aim of this work was to evaluate whether these plants interfere with the cardioprotection of HypoT after ischemia/reperfusion (I/R) in rats. In this model, HypoT was induced in rats by drinking methimazole for 15 days. Euthyroid (EuT) and HypoT rats drunk either Moff or Baf infusion during 7 days. Isolated perfused hearts were exposed to 20 min I/45min R inside a calorimeter, a model of stunning without infarct. Contractile pressure development (P, mmHg), diastolic pressure (LVEDP) and total heat rate (Ht, in mW/g) were measured. In EuT, Moff improved the postischemic contractile recovery (PICR) (105.0±16.4% of initial vs 69.4±6.0% in non-treated, p