Effect of anodised zirconium implants on early osseointegration process in adult rats: A histologic and histomorphometric study

TANO DE LA HOZ M.F.; KATUNAR M.R.; GONZÁLEZ A.; GOMEZ SANCHEZ A.; DÍAZ A.O.; CERÉ, S.

Progress in Biomaterials

Springer

Año: 2019

2194-0509

Since surface plays a key role in bioactivity, the response of the host to the biomaterial will determine the success of failure of the prosthesis. The purpose of this study is to make an exhaustive analysis of the histological and histochemical characteristics of new bone tissue around Zr implants anodised at 60V (Zr60) supported by histomorphometric methods in a rat model. Fibrous tissue was observed around the control implants (Zr0) and osteoblasts were identified on the trabeculae close to the implantation site that showed typical cytological characteristics of active secretory cells, regardless the surface condition. The histomorphometrical analysis revealed a significant increase in cancellous bone volume, trabecular thickness and in trabecular number together with a decrease in trabecular separation facing Zr60. TRAP staining showed that there was arelative increase in the number of osteoclasts for the Zr60. In addition, a larger number of osteroclast with a greater number of nuclei were detected in the tibiae for Zr60. This research demonstrated that the new bone microarchitecture in contact with Zr60 is able to improve the early stages of the osseointegration process and consequently the primary stability of implants which is a crucial factor to reduce recovery time for patients.