Antitumoral effects and calcemic activity of the novel analogue of calcitriol ML-344.

FERRONATO, M.J.; OBIOL, D.J.; ALONSO, E.N.; GUEVARA, J.A.; FERMENTO, M.E.; GANDINI, N.A.; MARIANI, F.; QUEVEDO, M.A.; FALL, Y.; RIVADULLA, M.G.; GÓMEZ, G.; CURINO, A.C.; FACCHINETTI, M.M.

Buenos Aires

Otro; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Investigación Clínica

The active form of vitamin D3, calcitriol, has been shown to displayantitumoral effects on various types of cancer. However, hypercalcemiais observed when effective antitumoral doses of calcitriol areemployed, thus precluding its therapeutic application. In collaborationwith the laboratory of Organic Chemistry of the University ofVigo we synthesized an analogue of calcitriol, called ML-344, inorder to obtain a compound that retain or even increase the antitumoralactivity but prevent the side effects. In this work we aimedto evaluate the biological effects of ML-344 by employing in vitro, invivo and in silico assays. We demonstrated that the analogue exertsa significant decrease in the viability of different cancer cell lines (p