INVESTIGADORES
ALVAREZ Diego Ezequiel
artículos
Título:
CHEMICAL OXIDATION OF SYNTHETIC IRON(III)-COMPLEX OF 15- PHENYL PROTOPORPHYRIN IX
Autor/es:
FERNANDO NIEMEVZ; DIEGO E. ALVAREZ; GRACIELA BULDAIN
Revista:
HETEROCYCLES
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2002 vol. 57 p. 697 - 704
ISSN:
0385-5414
Resumen:
Oxidative cleavage of 15-phenyl protohemin IX in pyridine solution in the presence of ascorbic acid (coupled oxidation), followed by esterification of the products with boron trifluoride-methanol rendered only three isomeric biliverdins. These were identified by 1H NMR and MS spectrometry as 10-phenyl biliverdin IXα (1), 5-phenyl biliverdin IXβ (2) and 15-phenyl biliverdin IXδ (3) dimethyl esters. The fact that biliverdin IXγ dimethyl ester derivative is not obtained indicates that oxidation fails to occur in the γ-meso-carbon bearing the phenyl group.
