Neurofibrillary Tangles and Al3+ Accumulation in Rajidae Electric Organ: an X-ray Microanalysis.

BARRERA F; FLORES VALERIO, W.,; PRADO FIGUEROA, M.

BIOCELL

INST HISTOL EMBRIOL-CONICET

Lugar: Mendoza; Año: 2005 vol. 29 p. 230 - 230

0327-9545

An association between the presence of Al3+, Si2+ and Alzheimer's disease (AD) has been reported. At the evidence of the accumulation of oxygen, Al3+ and Si2+ in Rajidae electrocyte by X-ray microanalysis, it was decided to explorer the presence of neurofibrillary tangles (NFT´s). Psammobatis extenta is an electrical fish from Rajidae family. According to their semicircle electrocyte shape, they are the less derived of this family. Electric organ cryostat sections of 8 μm of P. extenta, were performed along its anteroposterior axis; sections were treated by a modified Bielschowski method. It was observed this lesions, by a light microscope, distributed in the electrocyte cytoplasm. NFT´s have a circular shape and are around of 2-3 μm. In accompanied muscle cells, NFT´s are absent. This observation support the idea of an important role of Al3+ accumulation and oxidative stress in NFT´s development. In AD and in Rajidae electrocyte, cholinergic innervation are affected. P. extenta electrocyte can be use as an animal model for AD.