Chlorpyrifos promotes the migration of breast cáncer cells activating c-Src, Akt, Gsk-3β and p38 pathways

LASAGNA M; VENTURA C; HIELPOS S; MARDIROSIAN M; MIRET, N.; A RANDI; M NUÑEZ; COCCA C

Congreso; LXV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2020

SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC)

Chlorpyrifos (CPF) is a pesticide whose effects on breast cancer risk are not clear. Our aim was to analyze if CPF promotes migration and the pathways involved in MCF-7 and MDA-MB-231 cell lines. Migration was evaluated by 2D (wound healing and Boyden Chamber assays) and 3D assays (multicellular spheroids). c-Src, AKT, P38 and GSK3-β were studied by Western Blot. In MCF-7 cells, 0.05 μM CPF induced the migration after 48 h (p