INVESTIGADORES
SCHNITTGER Leonhard
artículos
Título:
Review: Theileria schizonts induce fundamental alterations in their host cells.
Autor/es:
AHMED JS, SCHNITTGER L, MEHLHORN H.
Revista:
PARASITOLOGY RESEARCH
Referencias:
Año: 1999 p. 527 - 538
ISSN:
0932-0113
Resumen:
The sporozoites of Theileria annulata and T. parva invade bovine
leukocytes, where they differentiate into schizonts. The latter can
immortalize and induce fundamental changes in their host cells. T.
annulata infects mainly major histocompatibility complex class II
cells, whereas T. parva preferentially transforms T-lymphocytes, which
proliferate continuously without the need for exogenously added growth
factors. Most of the cell lines appear to be independent of a growth
factor but may express several cytokines that influence the outcome of
the disease. The mechanisms underlying this transformation are not well
understood. The infected cells show increased activity of casein kinase
II and Jun NH2-terminal kinase (JNK), whereas extracellular
signal-related kinase 1 and 2 and P38 are not activated. In addition,
several transcriptional factors such as NFkB and AP-1 are activated. It
has been postulated that parasite proteins either expressed on the
surface of the schizonts or secreted into the host cell cytoplasm may
interfere with the signal-transduction pathway of the host cells. A
possible candidate may be the casein kinase II homologue that was
identified in schizonts of both T. annulata and T. parva.