INVESTIGADORES
SCHNITTGER Leonhard
artículos
Título:
HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection.
Autor/es:
MEYER CG, GALLIN M, ERTTMANN KD, BRATTIG N, SCHNITTGER L, GELHAUS A, TANNICH E, BEGOVICH AB, ERLICH HA, HORSTMANN RD
Revista:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Referencias:
Año: 1994 p. 7515 - 7519
ISSN:
0027-8424
Resumen:
Human infections with the tissue nematode Onchocerca volvulus result in
a variety of clinical conditions that possibly include protective
immunity. In a West African area hyperendemic for human onchocerciasis,
120 residents were classified according to clinical and laboratory
findings as presenting with generalized onchocerciasis, localized
onchocerciasis, or as being putatively immune. The three groups
differed in the distribution of HLA-D variants as determined by DNA
typing. The most pronounced differences were found among alleles of the
DQ loci. The haplotype DQA1*0501-DQB1*0301 was significantly more
frequent among putatively immune individuals than among patients with
generalized or localized disease. Conversely, DQA1*0101-DQB1*0501 and,
independently, the allele DQB1*0201 were more frequent in generalized
disease than in localized disease or putative immunity. In these
correlations, the frequencies of allelic variants were in localized
disease intermediate to those of the two other groups. The only
distinct association found with localized disease was that of the DP
allele DPB1*0402. The findings indicate that HLA-D variants influence
the course of O. volvulus infection and help to define a state that may
reflect protective immunity.