Lack of bone lesions at diagnosis is associated with inferior outcome in multisystem langerhans cell histiocytosis of childhood.

ARICÒ M; ASTIGARRAGA I; BRAIER JL; DONADIEU J; GADNER H; GLOGOVA E; GROIS N; HENTER JI; JANKA G; MCCLAIN KL; LADISCH S; PÖTSCHGER U; ROSSO D; THIEM E; WEITZMAN S; WINDEBANK K; MINKOV M

BRITISH JOURNAL OF HAEMATOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Año: 2014

0007-1048

Skeletal involvement is generally, but not universally, characteristic of Langerhans cell histiocytosis (LCH). We investigated whether the presence of bone lesions at diagnosis is a prognostic factor for survival in LCH. Nine hundred and thirty-eight children with multisystem (MS) LCH, both high (386 RO+) and low (RO-) risk, were evaluated for bone lesions at diagnosis. Risk organ (RO+) involvement was defined as: haematopoietic system (haemoglobin