INVESTIGADORES
PEREZ LLORET Santiago
congresos y reuniones científicas
Título:
Dysarthria in Parkinsons Disease patients: a cross-sectional survey
Autor/es:
SANTIAGO PEREZ-LLORET; LAURENCE NEGRE-PAGES; MARCELO MERELLO; OLIVIER RASCOL
Lugar:
Paris, Francia
Reunión:
Congreso; Congreso Internacional de Movimientos Anormales; 2009
Resumen:
Introduction:
Dysarthria is
commonly reported by patients with Parkinsons Disease (PD). However, this symptom has been rarely evaluated in large samples of
patients recruited out of tertiary specialized units and its prevalence, risk
factors and impact on health-related quality of life is poorly known in the
general PD population.
Objective: We explored the prevalence of dysarthria in 450 PD patients of the
Toulouse area in a cross-sectional study and compared the demographic, clinical
and pharmacological features and health-related quality of life associated with
the presence or absence of this symptom.
Methods: 450 patients were recruited in different academic and non-academic
outpatient neurological clinics and underwent structured standardized clinical
examination (UPDRS parts I-IV, MMSE, HADS, PDQ39). The presence of dysarthria
was defined as UPDRS II item 5 ≥ 1. Drug consumption was obtained from the clinical records.
Results: The mean age of the 450 studied patients was 69±10 years, 57% of them
were males, with a mean PD duration of 6±5 years, a mean UPDRS II+III in ON condition
of 28±15. They were treated with levodopa for 5±4 years with a mean daily dose
of 580±360 mg/day.
212 patients (51%) reported
dysarthria. Dysarthric patients had longer disease duration (7±3 vs 4±4 years, p<0.001),
greater UPDRS II+III score (36±16 vs 21±12, p<0.001), lower MMSE (27.9±2.2
vs 28.3±2.1, p=0.05), greater depression HADS score (7.3±3.7 vs 5.9±3.8,
p<0.0003), longer levodopa treatment (6±5 vs 4±3 years, p<0.0001) and
daily dose (651±391 vs 498±295, p<0.0001), more frequent amantadine treatment
(12% vs 4%, p<0.003) and higher PDQ39 score (30±13 vs 23±12, p<0.0001).
Conclusion:
Dysarthria affected 1 out of 2 patients of a large
sample of ambulatory PD patients recruited in various academic and non-academic
neurological outpatient clinics. Dysarthria was associated with more severe
indexes of parkinsonism and poorer health-related quality of life.