Validation of the Parkinson?s Disease Pain Symptoms Scale (PD-PSS): An interim report.

PEREZ LLORET, SANTIAGO; CIAMPI DE ANDRADE; HOLLENSTEIN N; MYLIUS V

Hong Kong

Congreso; 22th International Congress of Parkinson?s Disease and Movement Disorders; 2018

International Parkinson and Movement Disorders Society

Objectives: To explore the psychometric properties of the PD-PSS.Background: Evaluating pain in PD patients can be a difficult issue in the everyday clinical practice. To overcome this challenge we developed a dedicated questionnaire. Its main focus is to differentiate PD from non-PD related pains by means of three questions which correspond to the definition of PD-related pain (positive temporal relationship with PD, modified by motor fluctuations, or relieved by antiparkinsonian medications). If a PD related pain can be assumed due to a positive answer to at least one of the questions, the questionnaire allows to subdivide it into 3 different groups (musculoskeletal, neuropathic, or psychomotor restlessness pain) according to the character and the localisation. A final score including intensity, frequency as well as impact allows to rate the individual pain experience.Methods: 100 non-demented PD patients (in the ON-condition) were included in this interim report. Pain was assessed by the PD-PSS, DN4, Brief Pain Inventory (BPI) and McGill Pain Questionnaire short-form (MPQ-SF). Patients were also assessed by UPDRS III and IV, clock test, PDQ-8, HADS anxiety and Depression (HADS-A and HADS-D) and Wearing-off Questionaire 9 (WOQ-9).Results: 63 patients were males, mean±SD age was 63.2±12.1 ys, mean UPDRS III score in ON-state was 36.9±13.2. PD-unrelated pain was found in 19% of patients, musculoskeletal (MS) pain in 59%, neuropathic pain in 16% and psychomotor pain in 23%. Floor effects were observed in 12%, 0%, 26% and 36% of cases for MS, neuropathic, psychomotor subscores, and PD-PDSS total scores respectively. Ceiling effect was observed only in 7% of cases for MS pain. MS, neuropathic and psychomotor scores did not correlate significantly with each other. DN4 scores were higher in patients with neuropathic compared to MS (delta±SEM= 0.8±0.07 p