Risk of movement disorders with antipsychotic drugs in patients with Schizophrenia or Depressive Disorders

MARIA VERÓNICA REY; LUIS MOLINA; BYRON RECINOS; BEZNER PAZ; MAURICIO ROVELO; FANNY ELIZABETH RODRIGUEZ ELIAS; JOSÉ CALDERON; ARTURO ARELLANO; SANTIAGO POMATA; SANTIAGO PEREZ LLORET

Berlin

Congreso; The MDS 20th International Congress of Parkinson's Disease and Movement Disorders; 2016

International Parkinson's Disease and Movement Disorders Society

Objective: To compare the risk of movement disorders with antipsychotic drugs (APDs) in patients suffering fromSchizophrenia or Depressive Disorders.Background: APDs are well-known causes of movement disorders in schizophrenic patients. APDs are beingincreasingly used for depressive disorders. It remains unknown to what extent they increase the risk of movementdisorders in this population.Methods: 814 patients with a primary diagnosis of Schizophrenia (n=204) or depressive disorder such as BipolarDepression (n=343) or Major Depression (n=267) were recruited from psychiatric clinics in Guatemala, Honduras,El Salvador, Panama and Nicaragua. Presence of parkinsonism, dystonia, tardive dyskinesia, tremor, tics, andakathisia were explored by the Simpson-Angus and UKU scales.Results: Sixty-one patients (7.5%) had movement disorders (parkinsonism=10, dystonia=7, dyskinesias=3,tremor=34, tics=12, akathisia=16). Movement disorders were more frequent in Schizophrenia compared todepressive disorders (11% vs 6% respectively, p