INVESTIGADORES
PEREZ LLORET Santiago
artículos
Título:
Adverse drug reactions to dopamine agonists: a comparative study in the French Pharmacovigilance Database.
Autor/es:
SANTIAGO PEREZ-LLORET; EMMANUELLE BONDON-GUITTON; OLIVIER RASCOL; JEAN-LOUIS MONTASTRUC
Revista:
MOVEMENT DISORDERS
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Año: 2010 vol. 25 p. 1876 - 1880
ISSN:
0885-3185
Resumen:
Pharmacodynamical differences between dopamine agonists (DAs) suggest
differences in their adverse drug reactions (ADRs) profile. In this
study, frequencies of ADR to DAs or levodopa reports in the French
Pharmacovigilance Database were explored. Reports occurring between
January 1, 1984 and December 31, 2008 were selected (2,189 for DAs and
1,315 for levodopa). The numbers of ADRs by system organ class were
compared using ropinirole as a reference. Diurnal somnolence was less
frequently reported with all DAs when compared with ropinirole (P <
0.001). Impulse control disorders (ICDs) were more frequently reported
with pramipexole (P < 0.001). Significant difference was found among
DAs in the frequency of confusion or disorientation (P < 0.001),
nausea and vomiting (P < 0.05), or edemas (P < 0.001). No
difference among DAs was observed in the frequency of hallucination or
arterial hypotension ADR reports (P = 0.3 and P = 0.1). Pleural
effusions were more frequently reported with pergolide or bromocriptine
(P < 0.001). Somnolence or ICD reports were less frequent with
levodopa, whereas confusion was more frequently reported. In summary,
our data show significant differences in the kind of ADRs reported for
each DA.