INVESTIGADORES
PEREZ LLORET Santiago
artículos
Título:
Pregabalin-induced parkinsonism: a case report.
Autor/es:
SANTIAGO PEREZ-LLORET; MARIELA AMAYA; MARCELO MERELLO
Revista:
CLINICAL NEUROPHARMACOLOGY
Editorial:
LIPPINCOTT WILLIAMS & WILKINS
Referencias:
Año: 2009 vol. 32 p. 353 - 354
ISSN:
0362-5664
Resumen:
BACKGROUND: :
Pregabalin (PGB) is an L-type, voltage-dependent, calcium-channel
blocker, useful for the treatment of neuropathy pain and some forms of
seizures. We report the case of a 64-year-old woman who developed
full-blown parkinsonism after PGB administration.
CASE REPORT: :
A female patient who developed diabetic sensory-motor polyneuropathy
began treatment with gabapentin 300 mg plus amitriptyline 25 mg at the
age of 56 years, with good tolerance. Eight years later, PGB 150 mg was
added, after 3 months she developed a parkinsonian-like syndrome with
axial symptoms, bilateral symmetric postural tremor, bradykinesia, and
rigidity in both upper and lower limbs. Unified Parkinson's Disease
Rating Scale motor score was 27/108 points at this time. Clear link to
PGB introduction as well as symmetric limb involvement and symptom
intensity made us suspect drug-induced parkinsonism. Pregabalin was
withdrawn. Six months later, the patient had almost completely
recovered; her Unified Parkinson's Disease Rating Scale motor score
dropped to 4/108; and 3 months after that, it was 0.
CONCLUSION: :
Although some cases of tremor were reported in clinical trials on PGB,
to our knowledge, this is the first report of full-blown parkinsonism
associated with PGB use. Vigilance of PGB-treated patients is
recommended.