On the design of PNIPAm nanogels for biological applications. Synthesis, characterization and cellular assays

ABEL, SILVESTRE BONGIOVANNI; ANA LIAUDAT; FABRISIO ALUSTIZA; MARTINEZ, MARIA VICTORIA; PABLO BOCSH; C R. RIVAROLA; BARBERO, CESAR ALFREDO

Mar del Plata

Simposio; XVI SIMPOSIO LATINOAMERICANO DE POLÍMEROS-XIV CONGRESO IBEROAMERICANO DE POLÍMEROS; 2018

Instituto de Ciencia y Tecnología en Materiales (INTEMA)

Nanogels are nanosized crosslinked networkscomposed of hydrophilic or amphiphilic polymer chainsthat are capable of absorbing and releasing largequantities of its retained fluid (water, physiologicalfluids and/or drugs) bearing the characteristics of bothhydrogels and nanoparticles.1 Thermoresponsivepolymers undergo a phase transition at a certaintemperature in aqueous media known as phasetransition (Tp).3 Since the monomers are harmful tobiological species, biological effects of the nanogelsshould be evaluated prior to its application inbiomedicine. In this work, nanogels based on PNIPAm(a thermosensitive polymer) were synthesized,characterized, and evaluated using biological assays.