The Galectin-1-glycan Axis as a Key Modulator of Intestinal Inflammation in TNBS-induced Colitis in Mice.

MOROSI, LUCIANO; CUTINE, ANABELA; MORALES, ROSA; TOSCANO, MARTA A; RABINOVICH, GABRIEL A.; MARIÑO, KARINA VALERIA

Orlando, Florida

Congreso; Advances in Inflammatory Bowel Diseases 2016 (AIBD2016), Meeting de la Crohn and Colitis Foundation of America; 2016

Interactions between glycans and endogenous lectins are crucial in the development and resolution of many chronic inflammatory diseases. Galectin-1 (Gal-1) is a glycan-binding protein that recognizes N- and O-glycans bearing terminal lactosamine (Galβ(1-4)GlcNAc) units. However, modification of this structure with α(2,6) sialic acid is restrictive for Gal-1 binding. Gal-1 is capable of exerting immunomodulatory activity in different chronic inflammation models in mice, such as collagen-induced arthritis and experimental autoimmune encephalomyelitis. Administration of recombinant Gal-1 protects against the development of 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis, both in an acute and chronic TNBS-models. Nevertheless, the role of endogenous Gal-1 in mucosal homeostasis and intestinal immune regulation is still poorly understood. Results: TNBS-treated mice developed acute colitis both in WT (p