INVESTIGADORES
MARIÑO Karina Valeria
congresos y reuniones científicas
Título:
Mapping glycosylation-dependent pathways of gut homeostasis and inflammation
Autor/es:
MARIÑO, KARINA V.
Lugar:
San Francisco (Modalidad Virtual)
Reunión:
Simposio; Kenneth Rainin Foundation Innovations Symposium; 2022
Institución organizadora:
Kenneth Rainin Foundation
Resumen:
Ulcerative colitis (UC) is characterized by chronic and relapsing inflammation of the colon, and currently has no cure. Secretory IgA (SIgA), a heavily glycosylated complex produced by plasma cells (PCs), plays a key role in maintaining gut immune homeostasis. In many inflammatory pathologies including UC, aberrant glycosylation affects the function of immune cells and glycoproteins; however, the specific role of glycans in PCs and SIgA during gut inflammation has not been characterized. Thus, we started by analyzing glycosylation-related genes in single cell RNA-sequencing data from biopsies of UC patients. Notably, IgA+ PCs showed downregulation of genes involved in UDPGlcNAc and CMPsialic acid biosynthesis (UAP1, NANS) compared with controls (p
