PERSONAL DE APOYO
MILITELLO Rodrigo Damian
artículos
Título:
Small GTPases as regulators of cell division
Autor/es:
MILITELLO, RD; COLOMBO, MI
Revista:
Communicative & Integrative Biology
Editorial:
Landes Biosciences
Referencias:
Lugar: Austin, Texas; Año: 2013 vol. 6 p. 25461 - 25464
ISSN:
1942-0889
Resumen:
The superfamily of small GTPases serves as a signal transducer
to regulate a diverse array of cellular functions. The members of
this superfamily are structurally and functionally classified into
at least 5 groups (Ras, Rho/Rac, Rab, Arf, and Ran) and they are
involved in the control of cell proliferation and differentiation,
regulation of the actin cytoskeleton, membrane trafficking,
and nuclear transport. It is widely reported that members of the
Rab family participate in the control of intracellular membrane
trafficking through the interaction with specific effector
molecules. However, many Rabs and other small GTPases have
also been shown to function in cell division. In this review,
we discuss current knowledge about Rab proteins regulating
different stages of the cell cycle, such as the congregation and
segregation of chromosomes (during metaphase) and the final
stage of cell division known as cytokinesis, in which a cell is
cleaved originating 2 daughter cells.