Aldosterone stimulates the cardiac Na+/H+ exchanger via transactivation of the epidermal growth factor receptor.

DE GIUSTI VC; MARIELA NOLLY.; YEVES AM; CALDIZ CI; VILLA ABRILLE MC; CHIAPPE DE CINGOLANI GE;; ENNIS IL; CINGOLANI HE; CINGOLANI HE, PEREZ NG, AIELLO EA, ENNIS IL, GARCIARENA CD, VILLA-ABRILLE MC, DULCE RA, CALDIZ CI, YEVES AM, CORREA MV, NOLLY MB, CHIAPPE DE CINGOLANI G.

Congreso; High blood pressure research council of the American Heart Association. Orlando, Florida. 2011.; 2011

The use of antagonists of the mineralocorticoid receptor (MR) in the treatment of myocardial hypertrophy and heart failure has gained increasing importance in the last years. The up-regulation of the activity of the cardiac Na+/H+ exchanger (NHE-1) induced by aldosterone could account for the genesis of these pathologies. We tested whether aldosterone-induced NHE-1 stimulation involves the transactivation of the epidermal growth factor receptor (EGFR). Rat ventricular myocytes were used to measure intracellular pH with epifluorescence. pH data are presented as proton flux difference (DJH, mmol/L/min) between control and treatment at pHi 6.8 (* indicates p