Na+/H+ exchanger 1 (NHE1) hyperactivity is not critically involved in physiological cardiac hypertrophy: role of AKT.

A YEVES; MC VILLA-ABRILLE; MB NOLLY; NG PÉREZ; EM ESCUDERO; IL ENNIS

San Diego

Congreso; ISHR XXI World Congress, June 30 - July 4, 2013. San Diego, California.; 2013

ISHR (International Society for Heart Research)

NHE-1 hyperactivity plays a key role in pathological cardiac hypertrophy (CH) by increasing intracellular Na+ and Ca2+ concentrations and favouring the activation of calcineurin. Moreover, NHE-1 specific inhibition prevents and/or regresses pathological CH. However, it has not been yet elucidated its putative involvement in physiological CH. Since myocardial stretch, the activator of NHE-1, is a common event in both types of hypertrophy, we speculate that NHE-1 hyperactivity should be involved in both. Physiological CH was induced in rats by swimming (90 min/day, 12 weeks) [biventricular weight/tibia length: 22.0±0.3 vs. 24.3±0.7 mg/mm; sedentary (S) and trained (T); p