Influence of the ratio between Poloxamer 188 and Poloxamer 407 on praziquantel dissolution profiles from solid dispersions

SANTIAGO NICOLÁS CAMPOS ; AILÉN LARA SIBELLO; JOSÉ MARÍA BERMÚDEZ; CINTIA ALEJANDRA BRIONES NIEVA; MERCEDES VILLEGAS; ANALÍA IRMA ROMERO; ELIO EMILIO GONZO; ALICIA GRACIELA CID

Córdoba

Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas. RICiFa 2020+1; 2021

Praziquantel (PZQ) is a commonly used antiparasitic drug, but its pour solubility makes itsformulation difficult and causes a low bioavailability. In this work, solid dispersion (SD) technologywas used as an alternative to improve PZQ solubility and dissolution rate. SDs loaded with 50% w/wof PZQ were prepared by the fusion method using as carriers Poloxamer 188 (P188) and Poloxamer407 (P407) in different proportions (0%, 50% and 100% in P188). Dissolution tests were performedand dissolution profiles were analyzed and compared with the corresponding physical mixtures (PMs)using the Lumped model. The initial dissolution rates of SDs and PMs were 23.13 and 4.14 %/min for0%P188, 37.21 and 11.45 %/min for 50%P188, and 53.13 and 20.20 %/min for 100%P188,respectively, while it was 0.24 %/min for the pure PZQ. Although both PMs and SDs enhanced thedissolution rate and the solubility of PZQ, SDs showed a better performance increasing the initialdissolution rate more than PMs. Furthermore, 100%P188 SD presented a near 2-fold increase in thisparameter compared with 0% P188. These results allow concluding that PZQ SDs based on P188would represent a valuable alternative to improve its dissolution behavior.