New trends in the antimicrobial agents delivery using nanoparticles

JOSÉ M. BERMÚDEZ; ALICIA G. CID; ANALÍA I. ROMERO; MERCEDES VILLEGAS; NATALIA ANGEL VILLEGAS; SANTIAGO D. PALMA

Antimicrobial Nanoarchitectonics: From Synthesis to Applications

Elsevier

Lugar: Amsterdam; Año: 2017; p. 1 - 32

In recent years, there has been an unprecedented explosion of research and applications in the field of nanotechnology. Advances in nanotechnology have paved the way to the discovery of innumerable methods for prevention or treatment of various diseases. Nowadays, novel infectious diseases have emerged, many of which are responsible for life-threatening disorders. A lack of new antibiotics for treatment of illnesses, combined with the appearance of multi?drug-resistant strains, has generated the imperative requirement for innovative strategies in the development of newer antimicrobial therapies. In this context, one of the most active research areas of nanotechnology has been the development of nanoparticles, which has become the subject of interest of many research groups in a variety of fields. Nanoparticles with appropriate physicochemical properties can be taken up by cells of the body than much larger molecules. Drugs may be encapsulated, adsorbed or conjugated to the nanoparticles. These strategies impart uniqueness, which can lead to improved performance in many of dosage forms. Nanoparticles used for medical applications have to be biocompatible, biodegradable and nontoxic. The preparation and study of these novel drug delivery systems open unpredictable opportunities and result in biological and pharmacological applications to combating infectious diseases.