GELATIN/CELLULOSE nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case

FAVATELA, F.; HORST, M.F.; BRACONE, M.; GONZALEZ, J.; ALVAREZ, V.; LASSALLE, V.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

EDITIONS SANTE

Año: 2020

1773-2247

Gelatin based hydrogels were synthesized by the thawing- freezing method employinggum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) wasanalysed aiming to reach a control over the solubility/degradation rate, swelling propertiesand their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e:1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogelswere well characterized in terms of the main properties regarding the intended application.Hence the swelling behaviour, solubility rate, gel fraction were determined as well as theirthermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potentialapplication in the lidocaine administration during dental practices. This drug has beentaken as model between other potential therapeutic agents for buccal treatments such asantibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied bymeans of available mathematical models. The hydrogels loaded LID here presented wouldbe considered as potential raw materials to the fabrication of buccal patches in order toavoid, or at least minimize, the extensive use of injected anaesthesia during dentaltreatments.