Enhanced antimicrobial effect against early biofilm formation by combined action of micropatterned surfaces and antibiotics.

DÍAZ, C; MIÑÁN, A; SCHILARDI, P; FERNANDEZ LORENZO DE MELE, M

Natal

Congreso; VII Congresso Latino Americano de Órgãos Artificiais e Biomateriais - COLAOB 2012; 2012

The combined use of micropatterned surfaces and antibiotics on biofilms to reduce the rate of bacterial colonization is proposed. The adhesion of Pseudomonas fluorescens on microstructured (MS) and on nanostructured gold (NS) was assessed. MS- and NS-biofilms showed a decrease of five and two orders, respectively in the number of living cells with respect to the control after being treated with 4 mg/L of streptomycin (ST). We demonstrated that the combined action MS+ST is synergistic.