Striped, bioactive Ce-TiO2 material with peroxynitrite-scavenging activity

GRAVINA ANABELA NOEL; RUSO JUAN M.; LAIUPPA JUAN A.; SANTILLÁN GRACIELA E.; MARCO-BROWN, JOSÉ; D' ELÍA NOELIA LAURA; MESSINA PAULA VERÓNICA

JOURNAL OF MATERIALS CHEMISTRY

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2013 vol. 7 p. 834 - 845

0959-9428

Controlling aligned fiber microarchitectures to simulate extracellular matrix inducing important biological functions is a key challenge in regard to successful tissue regeneration. Here we present a bottomup microemulsion mediated strategy to obtain highly bioactive and biocompatible, striped CeTiO 2 nanocrystalline superstructures with ONOO scavenging activity. The employment of a bulkier organic ceria precursor on the material synthesis has several concurrently effects: (I) influencing the interfacial microemulsion droplet elasticity to create an aligned distribution of prismatic anatase nanoparticles causing the final lined morphology; (II) stabilizing the anatase active phase in a fine dispersed state and improving it resistance to the thermal anataserutile conversion; (III) indirectly favoring the rapid formation on the material surface of a hydroxyapatite layer composed of spherical like globules with 35 m in diameter essential for bonebonding; and finally (IV) accelerating the ONOO degradation to a less harmful species NO 2 and O 2.