p38 MAP kinase (p38) negatively regulates the slow force response (SFR) to myocardial stretch.

PÉREZ NG; DÍAZ RG; ZAVALA M; ENNIS IL; CINGOLANI HE; VILLA-ABRILLE MCM

Foz do Iguaçu

Congreso; 1st PanAmerican Congress of Physiological Sciences (PANAM); 2014

The SFR is the mechanical counterpart of a stretch-triggered autocrine mechanism that involves the release of angiotensin II/endothelin leading to the redox sensitive NHE1 phosphorylation/activation. Since p38 inhibition strengthens the angiotensin II-induced NHE1 activation in vascular smooth muscle, we hypothesized that it should modulate the SFR in the myocardium. In isolated rat papillary muscles the SFR was significantly increased by p38 inhibition with 10μmol/L SB202190, (27±2 vs 17±2 % of initial rapid phase, n=6, p